2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1360
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe 1038781-13-3 98%
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe is a nonimmunosuppressive cyclosporin A derivative. H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe has the potential for the research of congenital muscular dystrophy.
    H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
  • HY-P1415
    Norleual 334994-34-2 98%
    Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
    Norleual
  • HY-P1423
    BA 1 183241-31-8 98%
    BA 1 is a potent agonist for the bombesin (BB) family of receptors. BA 1 binds with high affinity to Bombesin receptor subtype-3 (BRS3), gastrin releasing peptide receptor (GRPR), neuromedin B receptor (NMBR) with IC50s of 6, 0.4, 2.5 nM.
    BA 1
  • HY-P1432
    K-(D-1-Nal)-FwLL-NH2 1394288-22-2 98%
    K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC50=3.4 nM, Ki=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity.
    K-(D-1-Nal)-FwLL-NH2
  • HY-P1433
    [Pro3]-GIP (Rat) 98%
    [Pro3]-GIP (Rat) is a selective GIP receptor partial agonist with a Ki of 13 nM. [Pro3]-GIP (Rat) can be used in diabetes research.
    [Pro3]-GIP (Rat)
  • HY-P1475
    C-Peptide, dog 39016-05-2 98%
    C-Peptide, dog is a component of proinsulin, released from pancreatic beta cells into blood together with insulin.
    C-Peptide, dog
  • HY-P1476
    Adrenocorticotropic Hormone (ACTH) (18-39), human 53917-42-3 98%
    Adrenocorticotropic Hormone (ACTH) (18-39), human is a corticotropinlike intermediate lobe peptide, which is produced in the melanotrophs of the intermediate lobe of the pituitary.
    Adrenocorticotropic Hormone (ACTH) (18-39), human
  • HY-P1481
    β-Casomorphin, human 102029-74-3 98%
    is an opioid peptide, acts as an agonist of opioid receptor.
    β-Casomorphin, human
  • HY-P1532
    Pancreatic Polypeptide, rat 90419-12-8 98%
    Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.
    Pancreatic Polypeptide, rat
  • HY-P1537
    Pancreatic Polypeptide, bovine 179986-89-1 98%
    Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
    Pancreatic Polypeptide, bovine
  • HY-P1544
    Cerebellin 94071-26-8 98%
    Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research.
    Cerebellin
  • HY-P1614
    ZEP-3 1026276-22-1 98%
    ZEP-3 is a tetrapeptide derivative with anti-aging activity for the skin. ZEP-3 can inhibit ROS production and alleviate oxidative stress.
    ZEP-3
  • HY-P1747
    Pneumadin, rat 130918-90-0 98%
    Pneumadin, rat (PNM) is a decapeptide, which possess a potent stimulating effect on arginine-vasopressin (AVP) release. Pneumadin, rat (PNM) exerts a marked antidiuretic effect in animals with functional AVP system.
    Pneumadin, rat
  • HY-P1773
    IGF-I (30-41) 82177-09-1 98%
    IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).
    IGF-I (30-41)
  • HY-P1776
    [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) 141171-54-2 98%
    [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) binds to insulin and can be used as insulin receptor tyrosine kinase substrates.
    [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
  • HY-P1790
    Axltide 143364-95-8 98%
    Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases.
    Axltide
  • HY-P1792
    Angiotensin II (1-4), human 52580-29-7 98%
    Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
    Angiotensin II (1-4), human
  • HY-P1800
    Caerulein, desulfated 20994-83-6 98%
    Caerulein, desulfated is the desulfurated form of Caerulein. Caerulein is a decapeptide having the same five carboxyl-terminal amino acids as gastrin and cholecystokinin (CCK).
    Caerulein, desulfated
  • HY-P1814
    TLQP-30 922704-13-0 98%
    TLQP-30 is a VGF peptide.
    TLQP-30
  • HY-P1841
    Glucagon-Like Peptide (GLP) II, human 89750-15-2 98%
    Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .
    Glucagon-Like Peptide (GLP) II, human
Cat. No. Product Name / Synonyms Application Reactivity